Liver Disease: Causes, Symptoms, Effects and Treatments

Liver Disease: Causes, Symptoms, Effects and Treatments CHAPTER 1 1.0 INTRODUCTION Liver is the organ which is most important, and it plays a pivotal role in regulating various processes in the body, such as storage, metabolism and secretion. It has great capacity to detoxify toxic substances to nontoxic substances and synthesize useful principles (Shanmugasundaram et al 2006). 1.1 Anatomy of the Liver The liver is a triangular organ that extends across the entire abdominal cavity inferior to diaphragm. Most of the liver’s mass is located on right side of body, where it descends inferiorly toward right kidney. The liver is madeup of very soft, pinkishbrown tissues encapsulated by connective tissue capsule. The capsule is covered and reinforced by the peritoneum of the abdominal cavity which protects liver and holds it in the place within abdomen. Liver consists of four distinct lobes first the left lobe, second the right lobe, third caudate lobe, and last quadrate lobe. The left and right lobes are the large lobes and are separated by the falciform ligament. The right lobe is about five to six times larger than tapered left lobe. The small caudate lobe extends from posterior side of the right lobe and it wraps around the inferior vena cava. Small quadrate lobe is inferior to the caudate lobe and it extends from the posterior side of the right lobe and it wraps around the gallbladder. Figure-1: Structure of liver. Functions of liver: Production of bile that required for the digestion of foods. Storage of extra sugar or glucose into stored glycogen in liver cells of the body and then converts it back into glucose when the the body needs it for energy. Production of clotting factors. Production of amino acids that is building blocks for making proteins, that includes those used to help fight infection. The production and storage of iron which is necessary for production of red blood cells in the body. Manufacturing of cholesterol and other chemical substances that is required for fat transport. Conversion of waste products of the metabolism into urea that is excreted in urine. Metabolising medicines into their active form (ingredient) in the body. 1.2 Liver diseases Liver disease is any disturbance in functions of the liver that cause illness. The liver is responsible for various critical functions in the body and when it becomes injured or diseased, loss of those functions can cause significant damage to body. Liver diseases are also referred as hepatic disease. 1.3 Types of liver diseases Alcoholic liver disease Primary liver cancer Cirrhosis Cysts Fatty liver disease Liver fibrosis Hepatitis Jaundice Primary sclerosing cholangitis 1.3.1 Alcoholic Liver Disease In 2000, cirrhosis was 1 of the leading causes of death in U.S.A. (United States). Alcoholic liver disease usually develops after large amount of alcohol intake. The long period during which alcohol excessively consumed, larger the amount ingested, high the rate of developing alcoholic liver disease and other liver problems. Signs and Symptoms: Confusion Excessive fluid between the membranes lining abdomen and abdominal organs Tenderness and abdominal pain Dry mouth Fever Fatigue Jaundice Weight gain Nausea Loss of appetite Abnormal dark or light skin Agitation Altered level of consciousness Breast development in males Difficulty concentrating Hallucinations Impaired judgment Paleness Redness on feet or hands 1.3.2 Primary Liver Cancer Primary cancer of the liver which is a growing liver problem called primary liver cancer, it generally remains undetected until when this disease has reached the advanced stage because most people do not exhibit these symptoms early on. Signs and Symptoms Jaundice that is yellow discoloration of skin. Abdominal pain (the upper right part of the abdomen) Swelling of abdomen An enlarged liver Fatigue General weakness Loss of appetite Nausea vomiting Weight loss 1.3.3 Liver Cirrhosis Liver cirrhosis is generally considered to the fourth stage of the alcoholic liver disease, it is progressive condition which causes liver damage. chronic alcoholism is the most common cause of this disease. 40% of the 27000 people die from this disease. Cirrhosis is characterized by the replacement of normal healthy tissue by fibrous tissue, regenerative nodules and scarring of the liver that is liver scarring. The resulting hardening of the liver, hard liver interferes with the blood circulation in the body, it leads to irreversible damage to the liver and a completely loss of liver function. Signs and Symptoms Abdominal accumulation of fluid in abdominal cavity Abnormal pain Bleeding from engorged veins in esophagus Dark cola-colored urine Exhaustion Gallstone Fatigue Diabetes type 2 Itchy hands and feet Loss of appetite Cancer of liver Liver failure Nausea and vomitting Malfunctioning of other systems such as impotence, kidney dysfunction and failure, and osteoporosis Hypertension Sensitivity to medications Spider-like small blood vessels under the skin Swelling of feet and hands from retained fluid Hepatic encephalopathy Weight loss Weakness jaundice Liver cysts Liver cyst also known as hepatic cyst, a simple liver cyst is a bubble (thin walled bubble), a fluid filled cavity in liver. A common liver problem, liver cyst can normal benign and pose no health risks. but in some cases, liver cyst may grow large enough to cause pain and discomfort in the abdomen, liver enlargement, infection of bile ducts, and bile ducts obstruction, that leads the cyst itself to become infected. In this case, it is necessary to drain and remove the cyst. Fatty Liver Disease Fatty Liver Diseases (steatosis) are generally considered to the first stage of Alcoholic Liver Disease. The exact causes of Non Alcoholic Fatty Liver Disease (NAFLD) are unclear. Many researchers, however, believe that the metabolic syndrome—a cluster of disorders that increase risk of diabetes, heart disease, and stroke—plays a crucial role in development of NAFLD. NAFLD Levels of Severity Simple fatty liver (steatosis). NASH (Non-alcoholic steatohepatitis), it is the inflammation and signs of necrosis. Cirrhosis is characterized by scarring of liver, results in a hard liver which is un-able to function proper. so Cirrhosis can be fatal. Signs and Symptoms Bleeding in esophagus from engorged veins Fatigue Fluid in the abdominal cavity Itching of feet and hands, and eventually entire body Loss of appetite Liver failure Lack of interest in sex Mentally confusion, such as forgetfulness and trouble concentrating Nausea and vomitting Small red spider veins under skin Swelling of feet and legs from retained fluid Weight loss Weakness Cola-colored urine Jaundice 1.3.6 Liver Fibrosis Liver fibrosis is generally considered to the third stage of Alcoholic Liver Disease, liver fibrosis is a liver condition which is very progressive. Liver fibrosis is characterised by the formation of the fibrous tissue, regenerative nodules and scarring of liver, which interfere circulation of blood and lead to loss of functions of liver. caused by chronic alcoholism and hepatitis C, cirrhosis is a disease which is degenerative disease of liver. Signs and Symptoms: Abdominal accumulation of fluids in abdomen Abnormal pain Bleeding from engorged veins in intestines or oesophagus Dark cola coloured urine Easy bruising Exhaustion Fatigue Itchy feet and hands Loss of appetite Lack of interest in sex Nausea and vomitting Swelling of feet and legs by retained fluid (edema) Enlargement of the liver Weakness Loss of weight Jaundice 1.3.7 Hepatitis Hepatitis is gastroenterological disease, means inflammation of liver. Hepatitis is not 1, but many diseases hepatitis A to E in which inflammation of liver occurs and its cells are damaged and then inflammatory chemicals are released and being produced in the liver. in some cases hepatitis B infection increases person’s chance to development of liver cancer by 100 times. Signs and Symptoms of Hepatitis: Diarrhea Dark urine Abdominal pain Enlarged liver Fever Fatigue General achiness Jaundice 1.3.8 Primary Sclerosing Cholangitis Cholangitis is inflammation of bile ducts of liver. Sclerosing is inflammation leads to the excessive formation of scar and fibrous tissue. In primary sclerosing cholangitis PSC, the bile ducts of the liver have become inflamed and scarred. 1.3.9 Jaundice It is not directly the disease of liver but rather symptom that can occur as result of variety of diseases. Jaundice appears a yellow discoloration of skin and white of the eyes caused by the abnormal formation of bilirubin in the blood. Orange yellowish pigment bilirubin, bilirubin is the part of bile, it forms in the liver as a byproduct of old cells of blood. When there are many blood cells (RBC) dying for liver to cope with yellowish pigment forms in the body resulting in jaundice, it is visible sign of liver problems. Jaundice is an indicator that a person is suffering from 1 of a many diseases including, Paracetamol toxicity Alcoholic liver diseases Autoimmune hepatitis An abnormal narrowing of the bile duct Blocked bile ducts caused by stones, infection, and tumors Chronic hepatitis Drug induced cholestasis, bile pools in the gallbladder as a result of certain drugs Drug induced hepatitis Fatty liver disease Hemolytic anemia Intra-hepatic cholestasis of pregnancy, bile pools in the gallbladder because of the pressure in the abdomen during pregnancy. Ischemic hepatocellular jaundice Pancreatic cancer Primary biliary cirrhosis Primary liver cancer Viral hepatitis Malaria Causes of liver disease Viral hepatitis Obesity Alcohol Genetics Autoimmune disorders Drugs Toxins Cancer Table-1 Types of hepatobiliary injury or damage 1.5 Mechanism of hepatotoxicity Distruption of cytoskeleton: phalloidin and microcystin disrupts the integrity of hepatocyte cytoskeleton by affecting proteins that are vital to its dynamic nature. (Phillips et al, 1986) Cholastasis: Bile formation is vulnerable to toxicant effects on the functional integrity of sinusoidal transporters, canalicular exporters, cytoskeleton dependent processes for transcytosis, and the contractile closure of the canalicular lumen.changes that weaken the junctions that form the structural barrier between the blood and the canalicular lumen allow solutes to leak out of the canalicular lumen. An immunosuppressive drug frequently reported to cause elevated level of serum bile salts and bilirubin as well as a reduction in bile flow. Mitochondrial damage: Preferential injury to mitochondrial DNA, as opposed to nuclear DNA, is a plausible mechanistic basis for structural and functional alterations to hepatic mitochondria associated with nucleoside analog therapy for hepatitis B and AIDS infections and with alcohol abuse. 1.6 Hepatotoxic agents Abacavir Acetaminophen Acitretin Alcohol Aldesleukin Amiodarone Amsacrine Anabolic steroids Androgens Asparaginase Bexarotene Carbamazepine Carmustine Cytarabine Dantrolene Dapsone Daunorubicin Disulfiram Divalproex Epirubicin Erythromycins Estrogens Ethionamide Etretinate Felbamate Fluconazole Flutamide Gold compounds Halothane HMG-CoA reductase inhibitors Imatinib Iron (overdose) Isoniazid Itraconazole Ketoconazole Labetalol Mercaptopurine Methimazole Methotrexate Methyldopa Metronidazole Naltrexone Nevirapine Niacin Nilutamide Nitrofurans Pemoline Phenothiazines Phenytoin Plicamycin Propylthiouracil Rifampin Rosiglitazone Sulfamethoxazole Sulfonamides Tacrine Tenofovir Tizanidine Tolcapone Toremifene Tretinoin Troleandomycin Valproic acid Vitamin A Zidovudine Lamivudine 1.7 Mechanisms of liver injury by some hepatotoxic substances 1.7.1 Mechanism of liver injury by CCl4 CCl4 converts into CCl3 and CCl3OO free radicals in the presence of enzyme CYP2E1, these free radicals then activate the inflammatory and profibrogenic mediators, inflammatory mediators cause lipid peroxidation and profibrogenic mediators cause liver fibrosis which are responsible for the liver injury. CCl4 also acstivates Tissue inhibitor of metalloproteinase 1 (TIMP-1), Tissue inhibitor of metalloproteinase 2 (TIMP-2), Matrix metalloproteinase 2 (MMP-2) and MMP-9 these expressions also activate profibrogenic mediators which cause liver fibrosis. Fig-2: Mechanism of liver injury by CCl4 1.7.2 Mechanism of liver injury by acetaminophen In therapeutic dose acetaminophen metabolises by glucuronyl transferases and sulfotransferases to stable metabolites which excreted throughout the body but in over dose acetaminophen metabolises by CYP2E1,CYP3A4 and CYP1A2 to toxic metabolite NAPQI(N-acetyl parabenzo quinine immine). this toxic metabolite covalently binds with the hepatocyte and causes damage to hepatocyte. After binding of NAPQI to hepatocyte there are two possibility, first is stimulation of CD44 receptor expression on T cell which recovers hepatocyte and second is the reduced expression of CD44 receptor on T cell causes hepatocyte apoptosis which is fatal condition to liver. Fig-3: (a)Liver injury by acetaminophen (b) Hepatocyte recovery and apoptosis process. 1.7.3 Mechanism of liver injury by alcohol Fig-4 : Pathways through which alcohol (ethanol) can contribute to apoptosis. 1.8 Hepatoprotection Hepatoprotection is the ability to prevent damage to the liver. One medicine of hepatoprotection is silymarin, derived from Milk Thistle which selectively inhibits formation of leukotrienes by Kupffer cells. 1.8.1 List of Herbs have potentially hepatoprotective constituents (Jia et al, 2011) Almond oil Ganoderma lucidum Glycyrrhiza glabra Arctium lappa Halenia elliptica Astragalus membranaceus Murraya koenigii Nymphaea stellata Ocimum sanctum Paeonia lactiflora Pergularia daemia Picrorhiza kurrooa Phyllanthus amarus Plumbago zeylanica Silybum marianum Scoparia dulcis Salvia miltiorrhiza Amomum xanthoides Astragalus membranaceus Cichorium intybus Curcuma longa Cajanus indicus, Centella asiatica Coccinia indica Brassica, Eclipta Flickingeria fimbriata Flickingeria fimbriata Ganoderma lucidum Glycyrrhiza glabra Halenia elliptica Murraya koenigii Nymphaea stellata Ocimum sanctum Paeonia lactiflora Pergularia daemia Picrorhiza kurrooa Phyllanthus amarus Plumbago zeylanica Silybum marianum Scoparia dulcis Salvia miltiorrhiza Scutellaria baicalensis Schisandra chinensis Table2: Plant tested in animal models for their hepatoprotective activity and found to be active. SBS PGI Balawala, DehradunPage 1

Mcdonalds – Tnc

McDonald's – the 90th largest economy in the world – feeds about 1 percent of the world's population a day. That's 68 million people! It hires more than 1 million workers In the US per year and Is the world's largest toy distributed. McDonald's also created the Ronald McDonald House charity, which houses more than 6000 families a year in Australia alone. However, this Illinois-based company is undeniably threatening the ‘global village'. It is doing so in a lot of ways, including the damage it inflicts to the environment, its exploitation of foreign and domestic labor and its active impacts on traditional cultures.In this seminar, I will be analyzing different pictures that support my argument that McDonald's Is directly destroying the global village. I think that through the Impacts It has upon the environment In which we live, McDonald's is directly destroying the global village. As a large company, McDonald's needs a lot of resources to fuel its growth. For exa mple, Americans alone consume over 1 billion pounds of beef at McDonald's every year. A cow produces 250 ml of methane per day on average. Think of how much methane is created by the sows needed to produce 1 billion pounds of beef!McDonald's has also been accused by Greenback of feeding Its chickens with soybeans grown on farms In the Amazon rainforest's. These soybean farms are cleared Illegally. Leading to mass deforestation In the Amazon. By doing this, McDonald's not only encourages illegal traders in the Amazon, but also sends a worldwide message that deforestation is a viable option that can lead to contracts selling produce to McDonald's. Encouraging excessive methane production and deforestation are Just a few of the ways in which McDonald's helps to destroy the environment.McDonald's also negatively affects the global village by exploiting members of the workforce. This Is done through the misuse of domestic and foreign labor. McDonald's has always been the target of accusa tions that they exploit teenage labor, paying them wages that are too low to be readily lived upon. These reduced rates can be seen in this table. But most recently McDonald's has tried to tackle these accusations head on by releasing an example budget for someone who works for the company. From the start this budget was flawed, as you can see here, the employee would have to work two Jobs to survive.This fact shows that an employee could not be sustained on a McDonald's wage. Secondly, McDonald's cited that health cover costs $20. This is not the case, for that amount you would be likely only to get say, ambulance cover. Thirdly, try spending only $25 a day on Just food, let alone drinks, clothes and other necessities. This budget on its own, is certain evidence that you would not be able to live on a McDonald's wage. In extreme cases some people have had to choose between paying bills and eating food.This exploitation of cheap labor is another reason why I think McDonald's Is cont ributing too diminished global village. McDonald's Is also destroying the global village by abolishing various cultures from around the world. As seen in the picture here, McDonald's is intervening with traditional culture, replacing traditional pastimes, like food-preparation and consumption, with an internationalists product. Often in these traditional cultures, things like food can be tied up with rituals, so food is linked to their cultural heritage.By replacing chance to pass on their cultural stories through food. However some people in other parts of the world have realized that this tragic loss of culture is occurring. For example, the people of a small town east of Melbourne called Tacoma has recently protested against there being a McDonald's built in the town. 80 000 people thus far have signed a petition demanding that a McDonald's franchise not be installed in their town. The fact that the company destroys culture and that people are realizing it is another reason that McDonald's is destroying the global village.

Problems in Education in the Phil

Problems and Issues in the Philippine Educational System Notes About the Problems and Issues in the Philippine Educational System: A Critical Discourse by Prof. John N. Ponsaran Colonial historiography. Most of the past and present teachers, book authors, and Social Studies consultants give heavier premium to the history of the colonizers in the Philippines, and not to the history of Filipinos. Mostly, this has been the case in the teaching of History subjects from the elementary to tertiary levels and will most likely perpetuate in the next generations to come.The history of the Filipino people and the colonial history of the Philippines are two different topics altogether. Internationalization of the division of labor. To a certain extent, the Philippine educational system conditions its students to be skillful in arithmetic and computer literacy, fluent in foreign languages (specifically English and Nihonggo), and docile in order to serve as workers of the transnational businesses of the advanced, capitalist countries. Take the case of the call center phenomenon in the Philippines, India and other developing states.Emasculation and demoralization of teachers. Teachers, more often than not, are victimized by the over-worked and under-paid policy of the system of the past and present dispensations. This leads to the emasculation and demoralization of their ranks. This probably explains why the teaching profession is not attracting the best and the brightest from the crop of students anymore. Expectedly, this will correspondingly result to the vicious cycle of mediocrity in education. Fly-by-night educational institutions. By any measure, the proliferation of fly-by-night educational institutions is counter-productive.In the long run, it produces a pool of half-baked, unprepared, and incompetent graduates. Alarmingly, the country is having an over-supply already. Some would even consider them as liabilities than assets. This case is true for both undergraduate and graduate studies. Culturally and gender insensitive educational system. Women, the common tao and the indigenous people are almost historically excluded from the Philippine historiography in favor of the men, heroes from Luzon and the power elite. Women are marginalized and trivialized even in language of education.Take the case of the terms female lawyer (as if lawyer as a profession is exclusive only to men) and manpower (which should have been human resources or human capital to be more politically correct). State abandonment of education. In the name of imperialist globalization, the state—in an incremental fashion—is abandoning its role to subsidize public education particularly in the tertiary level. This comes in the form of matriculation, laboratory and miscellaneous fee increases in order to force state colleges and universities (SCUs) to generate their own sources of fund.Ironically, the bulk of the budget (in fact, more than one-third in the case of 2005 National Budget) goes to debt servicing. Sub-standard textbooks. Some textbooks which are already circulation are both poorly written and haphazardly edited. Take the case of the Asya: Noon at Ngayon with an identified total number of more than 400 historical errors. Unfortunately, it is just one of the many other similar atrociously written textbooks which are yet to be identified and exposed. This is a classic case of profit-centeredness without regard to social accountability. Widespread contractualization.In the name of profit, owners and administrators of several private schools commonly practice contractualization among their faculty members. Contractual employees unlike their regular/tenured counterparts are not entitled to fringe benefits which consequently reduces the over-all cost of their business operation. Job insecurity demeans the ranks of the faculty members. Undue disregard for specialization. Some colleges and universities encourage their faculty pool to be genera lists (under the guise of multidisciplinary approach to learning) in order to be able to handle various subjects all at once.But some faculty members have turned out to be objects of mockery and have lost their self-esteem since some of them were pushed to handle Technical Writing, General Psychology, Filipino, and Algebra at the same time. This is prevalent among some franchised academic institutions even if the subjects are already off-tangent their area of interest and specialization. Copy-pasting culture. Over-dependence to the cyberspace has dramatically reduced the capability of students (even teachers) to undertake research. Copy-pasting’ has even turned into a norm among some students whenever they are tasked to submit a research paper or even a film review. Needless to say, plagiarism has already transformed into a more sophisticated form in the context of today’s electronic age. Mcdonaldized education. The system, methodology, and even content of education in the Philippines are mere haphazard transplantation from the West. It is therefore Eurocentric, culturally insensitive, and non-reflective of the local milieu.This is based on the xenocentric (foreign-centered) premise that other culture or system is far more superior than one’s own. The problem of non-sustainability and non-continuity. Teachers, administrators and publishers are all left in limbo whenever the DepEd would come up with another totally different directive from what it used to have in a rather very sudden interval. Take the case of the grading system, timeframe allotted to various subjects, MAKABAYAN program, readiness test, and learning competencies (LC). Poor regard for liberal art/education.Liberal education is intended to form a holistic individual equipped with communication, critical thinking, mathematical, creative, inter-personal and intra-personal skills. This explains why we also have Philosophy, Languages, Humanities, Natural Science, Social Science, Physical Education and even Theology in our college curriculum, and not only our major subjects. The curriculum is specifically designed to produce a total person, and not only a technical specialist. Unfortunately, the desired objective is not being met at all since liberal ducation is regarded only as a set of minor subjects. With the way these subjects are being handled (taking into account both content and methodology), students view the entire exercise as an unnecessary duplication of what they have already covered in high school. Equally alarming is the lack of enthusiasm and motivation exhibited by some professors to handle the subject especially if they believe that it has nothing to do with the course or area of specialization of their students (say, Art Appreciation for Accounting majors or Algebra for Creative Writing majors).Education a purveyor of myth. Education has been very effective in mainstreaming and perpetuating the social myths in a subtle and indirect manner. Some of these myths are the perceived superiority of white, educated men, ‘official’ history as advanced by the western point of view, globalization as the only way to achieve economic development, and stereotypes against the minoritized and the disenfranchised. Further marginalization of the undersubscribed courses.In the name of profit and as a response to the dictates of the market forces, colleges and universities prefer to offer more courses in line with the health sciences like nursing, medical transcription, and care-giving. This is done at the expense of the already undersubscribed yet relevant courses like Area Studies, Pilipinolohiya (Philippine Studies), Development Studies, Philippine Arts, Art Studies, Community Development, Social Work, Islamic Studies, Clothing Technology, and Ceramics Engineering. Monolithic education.Some educators in the name of conservatism and for the sake of convenience, prefer the old-style teaching paradigm where they view themsel ves as the fountain of knowledge and their students as nothing but empty vessels to be filled up (banking method of education). Modern education has ushered in learner-centered approach to education (from being the sage in the stage to just a guide on the side). Atrociously boring teachers. As I always underscore, there are no boring subjects, only boring teachers. But at least we should recognize them because they still serve a purpose. They serve as bad examples.

Australian republican debate 1999 - and the medias role

Australian republican debate 1999 - and the medias role The Australian media played a huge role in providing information to the Australian public during the republic debate that waged before the referendum in November 1999. By focusing on certain issues and particular people and failing to give the Australian public information on all of the issues of the debate, the Australian media helped sway the publics' opinion and therefore the out come of the referendum.During the constitution convention held in 1998 people representing many different groups concerned with the republic debate argued the main issues of this matter, and eventually came up with the blueprint of the proposed republic debate to be voted on by the people of Australia. The main issues that were discussed during the constitution convention were; the nomination and election of the president and the procedure that would be employed for this, the dismissal procedure of the president, the definition of powers the president would hold and the changes that would be made to the c onstitution and preamble.Australian Prime Minister Bob Hawke in the Pentago...Out of these issues the Australian media focused mainly on the nomination and election procedure of the president and the powers the president would hold. These issues were not only seen as newsworthy because of their importance to the republic debate, but because of the emotions and controversy they held. The issues were sensationalised as the major lobbying groups of the republic debate struggled to persuade the people of Australia on how to vote.The most controversial issue of the time was that of the election procedure of the president. The division between the direct election supporters and the indirect election supporters was debated in the morning newspapers, on the daytime radio and on the nightly news. The reason this argument was so sensationalised in the Australian media was that it split party lines. The republic...

Death of the Holocaust essays

Death of the Holocaust essays The Holocaust was one of if not the worst example of genocide and mass murder. The Nazis did one of the most horrible things imaginable by killing so many people. Some the death camps could be considered the worst places on earth, even worse then Hell. As one survivor put it, "No one can understand what happened here." The Nazi extermination and concentration camps at Auschwitz, Bergen-Belsen, Treblinka, Berkinow, Chelmo, Sobibor, Belzec, and hundreds of others kept prisoners on their toes and in a constant fear (The Nizkar Project). In these camps, over six million Jews were summarily killed simply because Hitler conceived them to be inferior to his Aryan race of Germans. Poland's Jewish population dropped from a vibrant 3,350,000 to a mere 50,000 by the end of the war, just to highlight the worst example (20th Century History). Alongside Gypsies, homosexuals, and some Slavs, Jews were especially targeted as utterly inferior and were subject to gassing, executions, medical experiments, and torture (The Nizkar Project). The deaths of these prisoners were utterly terrible. Some were shot from point blank one behind the next to save bullets. The Germans later used cyanide gas to kill the prisoners. This allowed the Germans to kill more people faster to save time and money. There was nothing innocent about the death camps. As you can see in the collage the bodies of the prisoners looked like skeletons with a thin layer of skin over their bones. The sites almost burn into your mind about how harsh and terrible this act was. The words "Work Makes You Free" adorned the gates to Auschwitz, the camp where the greatest number of Jews died (20th Century History). Fooled that if they worked they could go free, Jews were forced into the labor camps and into a life of constant fear, the constant threat of death, hard labor, starvation, sickness, and inhumanity. Auschwitz was the worst extermination camp of the Holocaust killing 1.1 million...

Privacy in Cyber Space Essay Example | Topics and Well Written Essays - 1000 words - 1

Privacy in Cyber Space - Essay Example The use of Internet as a basic mean of corporate usage has now become a critical business activity and therefore needs to be well-monitored as part of the important resources of any company (Cobb, 2002). However, the internet has also been of significant advantage to us in many ways. Where many of its services have benefited us in numerous ways, the email has had a significant character, besides other uses, in the commerce and trade sector. Email has proved to be the information and communication â€Å"Backbone† in most of the organizations (ColdSpark, 2007). It has been successfully used to facilitate the day to day business activities & processes, shared working environment, document transfer, corporate communication (both internal and external) and memorandums. According to the statistics, more than 35 percent of critical business information is found in companies is transferred via emails. Such a high figure means a high stance of dependency on the email service(s) and thus the nature of the content that is being transferred through these emails has actually forced many organizations to re-evaluate the significance of managing the email throughout its whole lifecycle. (ML Inc., 2008) Traditionally, the common practice was to retain the backup of all emails as per the IT department’s needs and cost factor. Now the environment has changed and therefore we need to manage this service as a strategic resource to take the best out of it. Email is considered now as a formal means of communication for any company, specially in a healthcare organizations where patients’ reports are treated with utmost confidentiality, which is no different from the traditional way of distributing the corporate information on the companies’ official letter head. This means that organizational or corporate emails are also bounded to abide by legal obligations of the state. Understanding the whole process of the collection,

Reflection Essay Example | Topics and Well Written Essays - 750 words - 20

Reflection - Essay Example Writing has helped me discover myself about my high points from a self-evaluated point of view. I strongly rely on spoken vocabulary. I write what I can say aloud making my writing direct and easily understood by others. Right from grade1 days I was told reading a lot builds our vocabulary and the greatest speakers in the world are equally chronic readers. At a personal point of view, my reading habit has greatly helped create the writer in me since it not only nurtures my grammar but also gives me a diversified approach to different situations. In addition, I constantly listen to my writing as if it were spoken aloud. This gives rhythm to my writing. Truth is highly compromised especially where the consequences that come with telling the truth are adverse making it subjective and objective and hence will now be propaganda and not factual. As a writer, I do not subscribe to such beliefs among people since I believe a writers duty is to tell the truth no matter how gross the circumstance is or whoever forms part of the story. I have a memory strong on recognition. I am not outstanding on recall but when someone or something triggers a memory, I retrieve it all a fresh with a new enticing version of it. I regard this rather advantageous as opposed to photographic memory, which impedes the imaginative process, which is why I am glad I do not have one. For a writer I suspect that recognition is more important than recall since when a memory of an individual is buried, all types of interesting links are formed in your mind. No machine is a hundred percent efficient, and as humans our efficiency is relatively lower than that hence I greatly embrace my weaknesses as I strive to work on them. Reluctance to edit is a major hiccup I face. When I am done with my writing, my mind drifts to something else and thus not unless I am willing I end up not editing the work. I have a phobia about fiction. When it comes to creating